In: Neuropsychobiology, 65 (2012), Nr. 3. pp. 147-152. ISSN 0302-282X
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Abstract
Introduction: According to the neurotrophin hypothesis, a brain-derived neurotrophic factor (BDNF) decrease has been postulated as a pivotal pathomechanism in affective disorder, and the treatment-associated increase in peripheral BDNF has been linked to therapeutic efficacy of antidepressant drugs and electroconvulsive therapy. However, in deep brain stimulation (DBS), a still experimental antidepressant treatment approach, this issue has not yet been investigated. Methods: We examine the long-term course of serum BDNF levels in a 64-year-old woman who is being treated with DBS of the lateral habenula for severe major depressive disorder. Results: Our main findings are a significant increase in BDNF serum levels following DBS of the lateral habenula and an inverse U-shaped correlation of depression scores and BDNF levels. Discussion: The data indicate that DBS, like other effective antidepressant treatments, may contribute to an increase in peripheral BDNF levels, which are thought to reflect central nervous DBS-induced neuroplastic changes. Moreover, our observations underscore the complex nature of disease-associated BDNF alterations. Their identification as either state or trait marker remains controversial and requires larger-scale longitudinal studies. Copyright (C) 2012 S. Karger AG, Basel
Document type: | Article |
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Journal or Publication Title: | Neuropsychobiology |
Volume: | 65 |
Number: | 3 |
Publisher: | S. Karger AG |
Date Deposited: | 11 Dec 2014 08:09 |
Date: | 2012 |
ISSN: | 0302-282X |
Page Range: | pp. 147-152 |
Faculties / Institutes: | Service facilities > Zentralinstitut für Seelische Gesundheit |
DDC-classification: | 610 Medical sciences Medicine |