Prolyl hydroxylase domain 2 protein is a strong prognostic marker in human gastric cancer

Kamphues, Carsten ; Wittschieber, Daniel ; Klauschen, Frederick ; Kasajima, Atsuko ; Dietel, Manfred ; Schmidt, Sven-Christian ; Glanemann, Matthias ; Bahra, Marcus ; Neuhaus, Peter ; Weichert, Wilko ; Stenzinger, Albrecht

In: Pathobiology, 79 (2012), Nr. 1. pp. 11-17. ISSN 1015-2008

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Abstract

Objective: According to recent research, prolyl hydroxylase domain 2 protein (PHD2) plays an important role in human carcinogenesis by inducing neovascularization and tumor growth. The aim of this study was to evaluate PHD2 expression patterns in primary gastric adenocarcinoma and to test for a potential predictive value of PHD2 expression in gastric cancer patients. Methods: In a total of 121 patients, PHD2 expression was investigated by immunohistochemistry in paraffin- embedded tissue and correlated with clinicopathological parameters and patient survival. Results: 64 of 121 gastric carcinomas (52.9%) showed PHD2 expression in tumor cell cytoplasm. In univariate analysis, PHD2- negative patients had a significantly shortened survival in comparison

Item Type:	Article
Journal or Publication Title:	Pathobiology
Volume:	79
Number:	1
Publisher:	S. Karger AG
Date Deposited:	11 Dec 2014 08:03
Date:	2012
ISSN:	1015-2008
Page Range:	pp. 11-17
Faculties / Institutes:	Medizinische Fakultät Heidelberg > Pathologisches Institut
Subjects:	610 Medical sciences Medicine