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Exposure of pregnant rats to cigarette-smoke condensate causes glomerular abnormalities in offspring

Zarzecki, Milosz ; Adamczak, Marcin ; Wystrychowski, Antoni ; Groß, Marie-Luise Pamela ; Ritz, Eberhard ; Wiecek, Andrzej

In: Kidney & blood pressure research, 36 (2012), Nr. 1. pp. 162-171. ISSN 1420-4096

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Background: Higher blood pressure and albuminuria are found in offspring of mothers who smoke during pregnancy. Whether or not kidney development is affected by maternal smoking is unknown. Methods: Sprague-Dawley rats were randomly allocated to twice-daily cigarette-smoke and nicotine condensate (1 mg/kg) or vehicle at day 10 of pregnancy until delivery. Results: Exposed offspring did not differ from control offspring with respect to body weight, kidney weight, albuminuria, and creatinine clearance. Both male and female offspring had higher tail-plethysmographic blood pressures and lower mean glomerular volume, podocyte, mesangial-cell, and endothelial-cell number, compared to control offspring. Conclusions: The data document that prenatal exposure to cigarette-smoke condensate containing nicotine influences normal kidney development and could predispose to higher blood pressures later in life. Copyright (c) 2012 S. Karger AG, Basel

Item Type: Article
Journal or Publication Title: Kidney & blood pressure research
Volume: 36
Number: 1
Publisher: S. Karger AG
Date Deposited: 11 Dec 2014 08:24
Date: 2012
ISSN: 1420-4096
Page Range: pp. 162-171
Faculties / Institutes: Medizinische Fakultät Heidelberg > Medizinische Universitäts-Klinik und Poliklinik
Medizinische Fakultät Heidelberg > Pathologisches Institut
Subjects: 610 Medical sciences Medicine
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