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Activation and maturation of peripheral blood T cells in HIV-1-infected and HIV-1-uninfected adults in Burkina Faso: a cross-sectional study

Tiba, Fabrice ; Nauwelaers, Frans ; Sangaré, Lassana ; Coulibaly, Boubacar ; Kräusslich, Hans-Georg ; Böhler, Thomas

In: Journal of the International AIDS Society, 14 (2011), Nr. 57. pp. 1-12. ISSN 1758-2652

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Download (724kB) | Lizenz: Creative Commons LizenzvertragActivation and maturation of peripheral blood T cells in HIV-1-infected and HIV-1-uninfected adults in Burkina Faso: a cross-sectional study by Tiba, Fabrice ; Nauwelaers, Frans ; Sangaré, Lassana ; Coulibaly, Boubacar ; Kräusslich, Hans-Georg ; Böhler, Thomas underlies the terms of Creative Commons Attribution 3.0 Germany

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Abstract

Background: We wanted to explore to what extent environmental exposure to immune stimulants, which is expected to be more present in rural than in urban settings, influences T cell activation and maturation in healthy and in HIV-1-infected individuals in Burkina Faso in west Africa. Methods: The proportion of circulating naïve T cells and the expression of the T cell activation markers, CD95 and CD38, were analyzed by immunophenotyping and three-colour flow cytometry in 63 healthy individuals and 137 treatment-naïve HIV-1-infected subjects from Ouagadougou (urban setting) and 26 healthy adults and 61 treatment-naïve patients from Nouna (rural). Results: A slightly higher activation level of CD4+ and CD8+ peripheral blood T cells was seen in healthy adults living in Nouna than in those living in Ouagadougou. The percentages of naïve CD45RAbright CCR7+ T cells were not significantly different between both study sites. Taking into consideration that relatively more HIV-1-infected patients in Nouna were in an advanced disease stage, no relevant differences were seen in T cell activation and maturation between patients at both study sites. As expected, the percentage of CD95+ CD4+ and CD38+ CD8+ T cells and the respective antigen density on these cells was significantly higher in patients than in controls in both settings. The percentage of naïve CD8+ T cells was lower in HIV-1-infected subjects than in healthy controls irrespective of the study site, while a lower proportion of naïve CD4+ T cells in patients compared with controls was seen only in Nouna. Conclusions: Environmentally triggered immune activation may contribute to the increased expression of the activation markers CD95 and CD38 on peripheral blood T cells from healthy adults living in rural versus urban settings in Burkina Faso. T cell activation is further increased in HIV-1-infected individuals due to T cell loss and high plasma viral load levels. The observed variations in T cell activation levels or the proportion of naïve T cells in our study patients, however, are not explained by differences in CD4+ T cell counts or HIV-1 plasma viral load levels alone.

Item Type: Article
Journal or Publication Title: Journal of the International AIDS Society
Volume: 14
Number: 57
Publisher: BioMed Central
Place of Publication: London
Date Deposited: 27 May 2015 07:25
Date: 2011
ISSN: 1758-2652
Page Range: pp. 1-12
Faculties / Institutes: Medizinische Fakultät Heidelberg > Department for Infectiology
Subjects: 610 Medical sciences Medicine
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