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Insights into the regulation of muscle metabolism and growth in mice and hibernating grizzly bears

Mugahid (Megahed), Douaa (Doaa)

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Mechanotransduction plays an important role in the regulation of muscle growth and metabolic signalling in striated muscle. Muscle disuse reduces mechanical input to the muscle, which results in a loss of muscle mass. Here I describe how titin's mechanically activated kinase domain affects muscle growth and metabolism via p62 and Akt signalling. I also demonstrate how changes in metabolic and growth signalling in hibernating grizzly bear help maintain muscle mass under conditions that induce muscle loss in humans and mice. I validated some of these changes in murine myotubes demonstrating that increasing non-essential amino acid levels, increasing Pdk4 levels or suppressing Serpinf1 has a positive effect on growth signalling that extends to non-hibernators.

Item Type: Dissertation
Supervisor: Kummer, Prof. Dr. Ursula
Date of thesis defense: 24 July 2015
Date Deposited: 26 Aug 2015 09:03
Date: 2015
Faculties / Institutes: The Faculty of Bio Sciences > Dean's Office of the Faculty of Bio Sciences
Subjects: 500 Natural sciences and mathematics
570 Life sciences
Controlled Keywords: Winterschlaf , MUSCLE, Stoffwechsel , Wachstum
Uncontrolled Keywords: Muscle, Hibernation, Metabolism, Growth, Cell size
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