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Specific CT 3D rendering of the treatment zone after Irreversible Electroporation (IRE) in a pig liver model: the “Chebyshev Center Concept” to define the maximum treatable tumor size

Vollherbst, Dominik ; Fritz, Stefan ; Zelzer, Sascha ; Wachter, Miguel F. ; Wolf, Maya B ; Stampfl, Ulrike ; Gnutzmann, Daniel ; Bellemann, Nadine ; Schmitz, Anne ; Knapp, Jürgen ; Pereira, Philippe L. ; Kauczor, Hans U. ; Werner, Jens ; Radeleff, Boris A. ; Sommer, Christof M.

In: BMC medical imaging, 14 (2014), Nr. 2. pp. 1-12. ISSN 1471-2342

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Download (3MB) | Lizenz: Creative Commons LizenzvertragSpecific CT 3D rendering of the treatment zone after Irreversible Electroporation (IRE) in a pig liver model: the “Chebyshev Center Concept” to define the maximum treatable tumor size by Vollherbst, Dominik ; Fritz, Stefan ; Zelzer, Sascha ; Wachter, Miguel F. ; Wolf, Maya B ; Stampfl, Ulrike ; Gnutzmann, Daniel ; Bellemann, Nadine ; Schmitz, Anne ; Knapp, Jürgen ; Pereira, Philippe L. ; Kauczor, Hans U. ; Werner, Jens ; Radeleff, Boris A. ; Sommer, Christof M. underlies the terms of Creative Commons Attribution 3.0 Germany

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Abstract

Background: Size and shape of the treatment zone after Irreversible electroporation (IRE) can be difficult to depict due to the use of multiple applicators with complex spatial configuration. Exact geometrical definition of the treatment zone, however, is mandatory for acute treatment control since incomplete tumor coverage results in limited oncological outcome. In this study, the “Chebyshev Center Concept” was introduced for CT 3d rendering to assess size and position of the maximum treatable tumor at a specific safety margin. Methods: In seven pig livers, three different IRE protocols were applied to create treatment zones of different size and shape: Protocol 1 (n = 5 IREs), Protocol 2 (n = 5 IREs), and Protocol 3 (n = 5 IREs). Contrast-enhanced CT was used to assess the treatment zones. Technique A consisted of a semi-automated software prototype for CT 3d rendering with the “Chebyshev Center Concept” implemented (the “Chebyshev Center” is the center of the largest inscribed sphere within the treatment zone) with automated definition of parameters for size, shape and position. Technique B consisted of standard CT 3d analysis with manual definition of the same parameters but position. Results: For Protocol 1 and 2, short diameter of the treatment zone and diameter of the largest inscribed sphere within the treatment zone were not significantly different between Technique A and B. For Protocol 3, short diameter of the treatment zone and diameter of the largest inscribed sphere within the treatment zone were significantly smaller for Technique A compared with Technique B (41.1 ± 13.1 mm versus 53.8 ± 1.1 mm and 39.0 ± 8.4 mm versus 53.8 ± 1.1 mm; p < 0.05 and p < 0.01). For Protocol 1, 2 and 3, sphericity of the treatment zone was significantly larger for Technique A compared with B. Conclusions: Regarding size and shape of the treatment zone after IRE, CT 3d rendering with the “Chebyshev Center Concept” implemented provides significantly different results compared with standard CT 3d analysis. Since the latter overestimates the size of the treatment zone, the “Chebyshev Center Concept” could be used for a more objective acute treatment control.

Item Type: Article
Journal or Publication Title: BMC medical imaging
Volume: 14
Number: 2
Publisher: BioMed Central
Place of Publication: London
Date Deposited: 24 Nov 2015 13:23
Date: 2014
ISSN: 1471-2342
Page Range: pp. 1-12
Faculties / Institutes: Service facilities > German Cancer Research Center (DKFZ)
Medizinische Fakultät Heidelberg > Medizinische Universitäts-Klinik und Poliklinik
Medizinische Fakultät Heidelberg > Chirurgische Universitätsklinik
Medizinische Fakultät Heidelberg > Radiologische Universitätsklinik
Medizinische Fakultät Heidelberg > Institut für Medizinische Biometrie und Informatik
Subjects: 610 Medical sciences Medicine
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