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Comparison of breast simultaneous integrated boost (SIB) radiotherapy techniques

Aly, Moamen M.O.M. ; Glatting, Gerhard ; Jahnke, Lennart ; Wenz, Frederik ; Madyan, Yasser

In: Radiation oncology, 10 (2015), Nr. 139. pp. 1-8. ISSN 1748-717X

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Download (1MB) | Lizenz: Creative Commons LizenzvertragComparison of breast simultaneous integrated boost (SIB) radiotherapy techniques by Aly, Moamen M.O.M. ; Glatting, Gerhard ; Jahnke, Lennart ; Wenz, Frederik ; Madyan, Yasser underlies the terms of Creative Commons Attribution 3.0 Germany

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Abstract

Purpose: To dosimetrically evaluate different breast SIB techniques with respect to target coverage and organs at risk (OARs) doses. Methods: Four IMRT techniques were compared in 12 patients. Three techniques employ tangential whole breast irradiation with either two coplanar fields (T-2F), or four non-coplanar fields (T-NC), or one Volumetric Modulated Arc Therapy (T-VMAT) for the boost volume. The fourth technique is a fully-modulated VMAT technique (f-VMAT). Dosimetric parameters were compared for the boost and breast target volumes as well as OARs. Delivery efficiency was analysed based on number of monitor units (MUs) and estimated delivery time. Results: T-VMAT and f-VMAT ranked highest with respect to integral assessment of boost and breast treatment quality measures. T-VMAT significantly outperformed f-VMAT with respect to ipsi-lateral lung and left-sided patients’ heart volumes ≥ 5 Gy (35 % ± 5 % vs. 52 % ± 6 % and 11 % ± 5 % vs. 22 % ± 6 %, respectively). f-VMAT significantly outperformed T-VMAT with respect to ipsi-lateral lung volume ≥ 20 Gy (13 % ± 2 % vs. 15 % ± 3 %) and heart volume ≥ 30 Gy in left breast cancer (0 % ± 0 % vs. 1 % ± 1 %). T-VMAT and f-VMAT needed 442 ± 58 and 1016 ± 152 MUs, respectively. Conclusions: The hybrid T-VMAT is considered the technique of choice due to its balance of quality, efficiency and dose to OARs.

Item Type: Article
Journal or Publication Title: Radiation oncology
Volume: 10
Number: 139
Publisher: BioMed Central
Place of Publication: London
Date Deposited: 30 Nov 2015 14:28
Date: 2015
ISSN: 1748-717X
Page Range: pp. 1-8
Faculties / Institutes: Medizinische Fakultät Mannheim > Klinik für Strahlentherapie und Radioonkologie
Subjects: 610 Medical sciences Medicine
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