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Factors influencing participation in a randomized controlled resistance exercise intervention study in breast cancer patients during radiotherapy

Gollhofer, Sandra M. ; Wiskemann, Joachim ; Schmidt, Martina E. ; Klassen, Oliver ; Ulrich, Cornelia M. ; Oelmann, Jan ; Hof, Holger ; Potthoff, Karin ; Steindorf, Karen

In: BMC Cancer, 15 (2015), Nr. 186. pp. 1-9. ISSN 1471-2407

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Download (451kB) | Lizenz: Creative Commons LizenzvertragFactors influencing participation in a randomized controlled resistance exercise intervention study in breast cancer patients during radiotherapy by Gollhofer, Sandra M. ; Wiskemann, Joachim ; Schmidt, Martina E. ; Klassen, Oliver ; Ulrich, Cornelia M. ; Oelmann, Jan ; Hof, Holger ; Potthoff, Karin ; Steindorf, Karen underlies the terms of Creative Commons Attribution 3.0 Deutschland

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Abstract

Background: Over the past years knowledge about benefits of physical activity after cancer is evolving from randomized exercise intervention trials. However, it has been argued that results may be biased by selective participation. Therefore, we investigated factors influencing participation in a randomized exercise intervention trial for breast cancer patients. Methods: Non-metastatic breast cancer patients were systematically screened for a randomized exercise intervention trial on cancer-related fatigue. Participants and nonparticipants were compared concerning sociodemographic characteristics (age, marital status, living status, travel time to the training facility), clinical data (body-mass-index, tumor stage, tumor size and lymph node status, comorbidities, chemotherapy), fatigue, and physical activity. Reasons for participation or declination were recorded. Results 117 patients (52 participants, 65 nonparticipants) were evaluable for analysis. Multiple regression analyses revealed significantly higher odds to decline participation among patients with longer travel time (p = 0.0012), living alone (p = 0.039), with more comorbidities (0.031), previous chemotherapy (p = 0.0066), of age ≥ 70 years (p = 0.025), or being free of fatigue (p = 0.0007). No associations were found with BMI or physical activity. By far the most frequently reported reason for declination of participation was too long commuting time to the training facility. Conclusions: Willingness of breast cancer patients to participate in a randomized exercise intervention study differed by sociodemographic factors and health status. Neither current physical activity level nor BMI appeared to be selective for participation. Reduction of personal inconveniences and time effort, e.g. by decentralized training facilities or flexible training schedules, seem most promising for enhancing participation in exercise intervention trials. Trial registration: Registered at ClinicalTrials.gov: NCT01468766 (October 2011).

Item Type: Article
Journal or Publication Title: BMC Cancer
Volume: 15
Number: 186
Publisher: BioMed Central
Place of Publication: London
Date Deposited: 09 Dec 2015 08:22
Date: 2015
ISSN: 1471-2407
Page Range: pp. 1-9
Faculties / Institutes: Service facilities > German Cancer Research Center (DKFZ)
Medizinische Fakultät Heidelberg > Radiologische Universitätsklinik
Subjects: 610 Medical sciences Medicine
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