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p16INK4a/Ki-67 dual stain cytology for cervical cancer screening in Thika district, Kenya

Wangari Ngugi, Caroline ; Schmidt, Dietmar ; Wanyoro, Karanja ; Boga, Hamadi ; Wanzala, Peter ; Muigai, Anne ; Mbithi, John ; von Knebel-Doeberitz, Magnus ; Reuschenbach, Miriam

In: Infectious agents and cancer, 10 (2015), Nr. 25. pp. 1-6. ISSN 1750-9378

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Download (580kB) | Lizenz: Creative Commons Lizenzvertragp16INK4a/Ki-67 dual stain cytology for cervical cancer screening in Thika district, Kenya by Wangari Ngugi, Caroline ; Schmidt, Dietmar ; Wanyoro, Karanja ; Boga, Hamadi ; Wanzala, Peter ; Muigai, Anne ; Mbithi, John ; von Knebel-Doeberitz, Magnus ; Reuschenbach, Miriam underlies the terms of Creative Commons Attribution 3.0 Germany

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Abstract

Background: The identification of suited early detection tests is one among the multiple requirements to reduce cervical cancer incidence in developing countries. Methods: We evaluated p16INK4a/Ki-67 dual-stain cytology in a screening population in Thika district, Kenya and compared it to high-risk human papillomavirus (HR-HPV) DNA testing and visual inspection by acetic acid (VIA) and Lugol’s iodine (VILI). Results: Valid results for all tests could be obtained in 477 women. 20.9 % (100/477) were tested positive for HR-HPV DNA, 3.1 % (15/477) had positive VIA/VILI and 8.2 % (39/477) positive p16INK4a/Ki-67 cytology. Of 22 women that showed up for colposcopy and biopsy, 6 women were diagnosed with CIN3 and two with CIN2. All women with CIN2/3 were negative in VIA/VILI screening and positive by HR-HPV DNA testing. But HPV was also positive in 91.7 % (11/12) of women with normal histology. p16INK4a/Ki-67 cytology was positive in all 6 women with CIN3, in one of the two CIN2 and in only 8.3 % (1/12) of women with normal histology. Conclusions: p16INK4a/Ki-67 cytology is an interesting test for further studies in developing countries, since our findings point to a lower fraction of false positive test results using p16INK4a/Ki-67 cytology compared to HPV DNA testing in a Kenyan screening population. VIA/VILI missed all histology-proven CIN2/3.

Item Type: Article
Journal or Publication Title: Infectious agents and cancer
Volume: 10
Number: 25
Publisher: BioMed Central
Place of Publication: London
Date Deposited: 14 Dec 2015 12:29
Date: 2015
ISSN: 1750-9378
Page Range: pp. 1-6
Faculties / Institutes: Medizinische Fakultät Heidelberg > Pathologisches Institut
Subjects: 570 Life sciences
610 Medical sciences Medicine
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