In: Genome Medicine, 7 (2015), Nr. 83. S. 1-7. ISSN 1756-994X
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Abstract
Incidental findings are the subject of intense ethical debate in medical genomic research. Every human genome contains a number of potentially disease-causing alterations that may be detected during comprehensive genetic analyses to investigate a specific condition. Yet available evidence shows that the frequency of incidental findings in research is much lower than expected. In this Opinion, we argue that the reason for the low level of incidental findings is that the filtering techniques and methods that are applied during the routine handling of genomic data remove these alterations. As incidental findings are systematically filtered out, it is now time to evaluate whether the ethical debate is focused on the right issues. We conclude that the key question is whether to deliberately target and search for disease-causing variations outside the indication that has originally led to the genetic analysis, for instance by using positive lists and algorithms.
Dokumententyp: | Artikel |
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Titel der Zeitschrift: | Genome Medicine |
Band: | 7 |
Nummer: | 83 |
Verlag: | BioMed Central |
Ort der Veröffentlichung: | London |
Erstellungsdatum: | 12 Jan. 2016 14:34 |
Erscheinungsjahr: | 2015 |
ISSN: | 1756-994X |
Seitenbereich: | S. 1-7 |
Institute/Einrichtungen: | Theologische Fakultät > Theologisches Seminar
Fakultät für Ingenieurwissenschaften > Institut für Pharmazie und molekulare Biotechnologie Zentrale und Sonstige Einrichtungen > Deutsches Krebsforschungszentrum Medizinische Fakultät Heidelberg und Uniklinikum > Medizinische Universitäts-Klinik und Poliklinik Medizinische Fakultät Heidelberg und Uniklinikum > Institut für Humangenetik |
DDC-Sachgruppe: | 200 Religion
570 Biowissenschaften, Biologie 610 Medizin |