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Apolipoprotein E-dependent load of white matter hyperintensities in Alzheimer’s disease: a voxel-based lesion mapping study

Morgen, Katrin ; Schneider, Michael ; Frölich, Lutz ; Tost, Heike ; Plichta, Michael M. ; Kölsch, Heike ; Rakebrandt, Fabian ; Rienhoff, Otto ; Jessen, Frank ; Peters, Oliver ; Jahn, Holger ; Luckhaus, Christian ; Hüll, Michael ; Gertz, Hermann-Josef ; Schröder, Johannes ; Hampel, Harald ; Teipel, Stefan J. ; Pantel, Johannes ; Heuser, Isabella ; Wiltfang, Jens ; Rüther, Eckart ; Kornhuber, Johannes ; Maier, Wolfgang ; Meyer-Lindenberg, Andreas

In: Alzheimer's Research & Therapy, 7 (2015), Nr. 27. pp. 1-14. ISSN 1758-9193

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Download (2MB) | Lizenz: Creative Commons LizenzvertragApolipoprotein E-dependent load of white matter hyperintensities in Alzheimer’s disease: a voxel-based lesion mapping study by Morgen, Katrin ; Schneider, Michael ; Frölich, Lutz ; Tost, Heike ; Plichta, Michael M. ; Kölsch, Heike ; Rakebrandt, Fabian ; Rienhoff, Otto ; Jessen, Frank ; Peters, Oliver ; Jahn, Holger ; Luckhaus, Christian ; Hüll, Michael ; Gertz, Hermann-Josef ; Schröder, Johannes ; Hampel, Harald ; Teipel, Stefan J. ; Pantel, Johannes ; Heuser, Isabella ; Wiltfang, Jens ; Rüther, Eckart ; Kornhuber, Johannes ; Maier, Wolfgang ; Meyer-Lindenberg, Andreas underlies the terms of Creative Commons Attribution 3.0 Germany

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Abstract

Introduction: White matter (WM) magnetic resonance imaging (MRI) hyperintensities are common in Alzheimer’s disease (AD), but their pathophysiological relevance and relationship to genetic factors are unclear. In the present study, we investigated potential apolipoprotein E (APOE)-dependent effects on the extent and cognitive impact of WM hyperintensities in patients with AD. Methods: WM hyperintensity volume on fluid-attenuated inversion recovery images of 201 patients with AD (128 carriers and 73 non-carriers of the APOE ε4 risk allele) was determined globally as well as regionally with voxel-based lesion mapping. Clinical, neuropsychological and MRI data were collected from prospective multicenter trials conducted by the German Dementia Competence Network. Results: WM hyperintensity volume was significantly greater in non-carriers of the APOE ε4 allele. Lesion distribution was similar among ε4 carriers and non-carriers. Only ε4 non-carriers showed a correlation between lesion volume and cognitive performance. Conclusion: The current findings indicate an increased prevalence of WM hyperintensities in non-carriers compared with carriers of the APOE ε4 allele among patients with AD. This is consistent with a possibly more pronounced contribution of heterogeneous vascular risk factors to WM damage and cognitive impairment in patients with AD without APOE ε4-mediated risk.

Item Type: Article
Journal or Publication Title: Alzheimer's Research & Therapy
Volume: 7
Number: 27
Publisher: BioMed Central
Place of Publication: London
Date Deposited: 14 Jan 2016 10:00
Date: 2015
ISSN: 1758-9193
Page Range: pp. 1-14
Faculties / Institutes: Medizinische Fakultät Mannheim > Mannheimer Institute of Public Health (MIPH)
Service facilities > Zentralinstitut für Seelische Gesundheit
Medizinische Fakultät Heidelberg > Psychiatrische Universitätsklinik
Subjects: 610 Medical sciences Medicine
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