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Gene expression of inflammasome components in peripheral blood mononuclear cells (PBMC) of vascular patients increases with age

Wu, Xiaoyu ; Hakimi, Maani ; Wortmann, Markus ; Zhang, Jian ; Böckler, Dittmar ; Dihlmann, Susanne

In: Immunity & Ageing, 12 (2015), Nr. 15. pp. 1-5. ISSN 1742-4933

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Download (839kB) | Lizenz: Creative Commons LizenzvertragGene expression of inflammasome components in peripheral blood mononuclear cells (PBMC) of vascular patients increases with age by Wu, Xiaoyu ; Hakimi, Maani ; Wortmann, Markus ; Zhang, Jian ; Böckler, Dittmar ; Dihlmann, Susanne underlies the terms of Creative Commons Attribution 3.0 Germany

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Abstract

Background: Chronic low-grade inflammation is considered a driver of many age-related disorders, including vascular diseases (inflammaging). Inhibition of autophagic capacity with ageing was postulated to generate a pro-inflammatory condition via activation of inflammasomes, a group of Interleukin-1 activating intracellular multi-protein complexes. We thus investigated gene expression of inflammasome components in PBMC of 77 vascular patients (age 22–82) in association with age. Findings: Linear regression of real-time qRT-PCR data revealed a significant positive association of gene expression of each of the inflammasome components with age (Pearson correlation coefficients: AIM2: r = 0.245; P = 0.032; NLRP3: r = 0.367; P = 0.001; ASC (PYCARD): r = 0.252; P = 0.027; CASP1: r = 0.296; P = 0.009; CASP5: r = 0.453; P = 0.00003; IL1B: r = 0.247; P = 0.030). No difference in gene expression of AIM2, NLRP3, ASC CASP1, and CASP5 was detected between PBMC of patients with advanced atherosclerosis and other vascular patients, whereas IL1B expression was increased in PBMC of the latter group (P = 0.0005). Conclusion: The findings reinforce the systemic pro-inflammatory phenotype reported in elderly by demonstrating an increased phase-1 activation of inflammasomes in PBMC of vascular patients.

Item Type: Article
Journal or Publication Title: Immunity & Ageing
Volume: 12
Number: 15
Publisher: BioMed Central
Place of Publication: London
Date Deposited: 25 Jan 2016 08:35
Date: 2015
ISSN: 1742-4933
Page Range: pp. 1-5
Faculties / Institutes: Medizinische Fakultät Heidelberg > Chirurgische Universitätsklinik
Subjects: 610 Medical sciences Medicine
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