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Validity and responsiveness of the EQ-5D in assessing and valuing health status in patients with somatoform disorders

Brettschneider, Christian ; König, Hans-Helmut ; Herzog, Wolfgang ; Kaufmann, Claudia ; Schäfert, Rainer ; Konnopka, Alexander

In: Health and quality of life outcomes, 11 (2013), Nr. 3. pp. 1-12. ISSN 1477-7525

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Download (270kB) | Lizenz: Creative Commons LizenzvertragValidity and responsiveness of the EQ-5D in assessing and valuing health status in patients with somatoform disorders by Brettschneider, Christian ; König, Hans-Helmut ; Herzog, Wolfgang ; Kaufmann, Claudia ; Schäfert, Rainer ; Konnopka, Alexander underlies the terms of Creative Commons Attribution 3.0 Germany

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Abstract

Background: The EQ-5D is a generic questionnaire providing a preference-based index score applicable to cost-utility analysis. This is the first study to validate the EQ-5D in patients with somatoform disorders. Methods: Data of the EQ-5D descriptive system, the British and the German EQ-5D index and the EQ Visual Analogue Scale, the Patient Health Questionnaire 15, the Patient Health Questionnaire 9, the Whiteley Index 7 and the Short Form 36 were collected from 294 patients at baseline, 244 at 6 months and 256 at 12 months after baseline. The discriminative ability of the EQ-5D was evaluated by comparison with a general population sample and by the ability to distinguish between different symptom severities. Convergent validity was analysed by assessing associations between the EQ-5D and the other instruments. Responsiveness was evaluated by analysing the effects on scores between two measurements in groups of patients reporting worse, same or better health. The Bonferroni correction was employed. Results: For all items of the EQ-5D except ‘self-care’, patients with somatoform disorders reported more problems than the general population. The EQ-5D showed discriminative ability in patients with different symptom severities. For nearly all reference instruments there were significant differences in mean scores between respondents with and without problems in the various EQ-5D items and strong correlations with the EQ Visual Analogue Scale and the EQ-5D index scores. Evidence for the responsiveness of the EQ-5D could only be found for patients with better health; effects were medium at the utmost. Conclusions: The EQ-5D showed a considerable validity and a limited responsiveness in patients with somatoform disorders. Trial registration: Current Controlled Trials ISRCTN55280791

Item Type: Article
Journal or Publication Title: Health and quality of life outcomes
Volume: 11
Number: 3
Publisher: BioMed Central
Place of Publication: London
Date Deposited: 03 Feb 2016 10:29
Date: 2013
ISSN: 1477-7525
Page Range: pp. 1-12
Faculties / Institutes: Medizinische Fakultät Heidelberg > Psychosomatische Universitätsklinik
Subjects: 610 Medical sciences Medicine
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