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The history of neuromyelitis optica

Jarius, Sven ; Wildemann, Brigitte

In: Journal of Neuroinflammation, 10 (2013), Nr. 8. pp. 1-12. ISSN 1742-2094

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The discovery of a novel serum autoantibody (termed NMO-IgG or AQP4-Ab) in a subset of patients in 2004 has revived interest in neuromyelitis optica (NMO). While the history of classical multiple sclerosis has been extensively studied, only little is known about the history of NMO. In the present article, we provide a comprehensive review of the early history of this rare but intriguing syndrome. We trace the origins of the concept of NMO in the 19th century medical literature and follow its evolution throughout the 20th and into the 21st century. Finally, we discuss recent proposals to revise the concept of NMO and explain why there is indeed a need for a more systematic and descriptive nomenclature.

Item Type: Article
Journal or Publication Title: Journal of Neuroinflammation
Volume: 10
Number: 8
Publisher: BioMed Central
Place of Publication: London
Date Deposited: 17 Feb 2016 10:47
Date: 2013
ISSN: 1742-2094
Page Range: pp. 1-12
Faculties / Institutes: Service facilities > Interdisziplinäres Zentrum für Neurowissenschaften
Medizinische Fakultät Heidelberg > Neurologische Universitätsklinik
Subjects: 610 Medical sciences Medicine
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