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Mechanisms of disturbed emotion processing and social interaction in borderline personality disorder: state of knowledge and research agenda of the German Clinical Research Unit

Schmahl, Christian ; Herpertz, Sabine C. ; Bertsch, Katja ; Ende, Gabriele ; Flor, Herta ; Kirsch, Peter ; Lis, Stefanie ; Meyer-Lindenberg, Andreas ; Rietschel, Marcella ; Schneider, Miriam ; Spanagel, Rainer ; Treede, Rolf-Detlef ; Bohus, Martin

In: Borderline Personality Disorder and Emotion Dysregulation, 1 (2014), Nr. 12. pp. 1-17. ISSN 2051-6673

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Download (569kB) | Lizenz: Creative Commons LizenzvertragMechanisms of disturbed emotion processing and social interaction in borderline personality disorder: state of knowledge and research agenda of the German Clinical Research Unit by Schmahl, Christian ; Herpertz, Sabine C. ; Bertsch, Katja ; Ende, Gabriele ; Flor, Herta ; Kirsch, Peter ; Lis, Stefanie ; Meyer-Lindenberg, Andreas ; Rietschel, Marcella ; Schneider, Miriam ; Spanagel, Rainer ; Treede, Rolf-Detlef ; Bohus, Martin underlies the terms of Creative Commons Attribution 3.0 Germany

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Abstract

The last two decades have seen a strong rise in empirical research in the mechanisms of emotion dysregulation in borderline personality disorder. Major findings comprise structural as well as functional alterations of brain regions involved in emotion processing, such as amygdala, insula, and prefrontal regions. In addition, more specific mechanisms of disturbed emotion regulation, e.g. related to pain and dissociation, have been identified. Most recently, social interaction problems and their underlying neurobiological mechanisms, e.g. disturbed trust or hypersensitivity to social rejection, have become a major focus of BPD research. This article covers the current state of knowledge and related relevant research goals. The first part presents a review of the literature. The second part delineates important open questions to be addressed in future studies. The third part describes the research agenda for a large German center grant focusing on mechanisms of emotion dysregulation in BPD.

Item Type: Article
Journal or Publication Title: Borderline Personality Disorder and Emotion Dysregulation
Volume: 1
Number: 12
Publisher: BioMed Central
Place of Publication: London
Date Deposited: 02 Mar 2016 07:26
Date: 2014
ISSN: 2051-6673
Page Range: pp. 1-17
Faculties / Institutes: Medizinische Fakultät Mannheim > Zentrum für Biomedizin und Medizintechnik (CBTM)
Service facilities > Zentralinstitut für Seelische Gesundheit
Medizinische Fakultät Heidelberg > Psychiatrische Universitätsklinik
Subjects: 610 Medical sciences Medicine
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