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Neurological outcome after emergency radiotherapy in MSCC of patients with non-small cell lung cancer - a prospective trial

Rief, Harald ; Heinhold, Rita C. ; Petersen, Lina C. ; Rieken, Stefan ; Bruckner, Thomas ; Moghaddam-Alvandi, Arash ; Debus, Jürgen ; Sterzing, Florian

In: Radiation Oncology, 8 (2013), Nr. 297. pp. 1-5. ISSN 1748-717X

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Download (309kB) | Lizenz: Creative Commons LizenzvertragNeurological outcome after emergency radiotherapy in MSCC of patients with non-small cell lung cancer - a prospective trial by Rief, Harald ; Heinhold, Rita C. ; Petersen, Lina C. ; Rieken, Stefan ; Bruckner, Thomas ; Moghaddam-Alvandi, Arash ; Debus, Jürgen ; Sterzing, Florian underlies the terms of Creative Commons Attribution 3.0 Germany

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Abstract

Background: The aim of this trial was to investigate neurological outcome after emergency RT in MSCC of NSCLC patients with acute neurological deficit. Methods This pilot trial was prospective, non-randomized, and monocentre, ten patients were treated from July 2012 until June 2013. After onset of neurological symptoms RT was started within 12 hours. The neurological outcome was assessed at baseline, and six weeks after RT using the ASIA Impairment Scale (AIS). Results: The results showed an improved neurological outcome in one patient (10%), one patient (10%) had a decreased, and five patients (50%) a constant outcome after six weeks. Three patients (30%) died within the first six weeks following RT, additional 4 patients (40%) died within 4 month due to tumor progression. Conclusion: In this group of NSCLC patients we were able to show that emergency RT in MSCC with acute neurological deficit had no considerable benefit in neurological outcome. Therefore, short-course regime or best supportive care due to poor survival should be considered for these patients with additional distant metastases. Patients with favorable prognosis may be candidates for long-course RT. Trial Registration: Clinical trial identifier http://www.clinicaltrials.gov/

Item Type: Article
Journal or Publication Title: Radiation Oncology
Volume: 8
Number: 297
Publisher: BioMed Central
Place of Publication: London
Date Deposited: 07 Apr 2016 09:01
Date: 2013
ISSN: 1748-717X
Page Range: pp. 1-5
Faculties / Institutes: Medizinische Fakultät Heidelberg > Orthopädische Klinik
Medizinische Fakultät Heidelberg > Radiologische Universitätsklinik
Medizinische Fakultät Heidelberg > Institut für Medizinische Biometrie und Informatik
Subjects: 610 Medical sciences Medicine
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