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One life ends, another begins: Management of a brain-dead pregnant mother - A systematic review -

Esmaeilzadeh, Majid ; Dictus, Christine ; Kayvanpour, Elham ; Sedaghat-Hamedani, Farbod ; Eichbaum, Michael ; Hofer, Stefan ; Engelmann, Guido ; Fonouni, Hamidreza ; Golriz, Mohammad ; Schmidt, Jan ; Unterberg, Andreas ; Mehrabi, Arianeb ; Ahmadi, Rezvan

In: BMC Medicine, 8 (2010), Nr. 74. pp. 1-11. ISSN 1741-7015

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Download (1MB) | Lizenz: Creative Commons LizenzvertragOne life ends, another begins: Management of a brain-dead pregnant mother - A systematic review - by Esmaeilzadeh, Majid ; Dictus, Christine ; Kayvanpour, Elham ; Sedaghat-Hamedani, Farbod ; Eichbaum, Michael ; Hofer, Stefan ; Engelmann, Guido ; Fonouni, Hamidreza ; Golriz, Mohammad ; Schmidt, Jan ; Unterberg, Andreas ; Mehrabi, Arianeb ; Ahmadi, Rezvan underlies the terms of Creative Commons Attribution 3.0 Germany

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Abstract

Background: An accident or a catastrophic disease may occasionally lead to brain death (BD) during pregnancy. Management of brain-dead pregnant patients needs to follow special strategies to support the mother in a way that she can deliver a viable and healthy child and, whenever possible, also be an organ donor. This review discusses the management of brain-dead mothers and gives an overview of recommendations concerning the organ supporting therapy. Methods: To obtain information on brain-dead pregnant women, we performed a systematic review of Medline, EMBASE and the Cochrane Central Register of Controlled Trials (CENTRAL). The collected data included the age of the mother, the cause of brain death, maternal medical complications, gestational age at BD, duration of extended life support, gestational age at delivery, indication of delivery, neonatal outcome, organ donation of the mothers and patient and graft outcome. Results: In our search of the literature, we found 30 cases reported between1982 and 2010. A nontraumatic brain injury was the cause of BD in 26 of 30 mothers. The maternal mean age at the time of BD was 26.5 years. The mean gestational age at the time of BD and the mean gestational age at delivery were 22 and 29.5 weeks, respectively. Twelve viable infants were born and survived the neonatal period. Conclusion: The management of a brain-dead pregnant woman requires a multidisciplinary team which should follow available standards, guidelines and recommendations both for a nontraumatic therapy of the fetus and for an organ-preserving treatment of the potential donor.

Item Type: Article
Journal or Publication Title: BMC Medicine
Volume: 8
Number: 74
Publisher: BioMed Central; Springer
Place of Publication: London; Berlin; Heidelberg
Date Deposited: 26 Jul 2016 08:46
Date: 2010
ISSN: 1741-7015
Page Range: pp. 1-11
Faculties / Institutes: Medizinische Fakultät Heidelberg > Medizinische Universitäts-Klinik und Poliklinik
Medizinische Fakultät Heidelberg > Chirurgische Universitätsklinik
Medizinische Fakultät Heidelberg > Universitätsklinik für Anaesthesiologie
Medizinische Fakultät Heidelberg > Universitäts-Frauenklinik
Medizinische Fakultät Heidelberg > Universitätskinderklinik
Medizinische Fakultät Heidelberg > Neurochirurgische Universitätsklinik
Subjects: 610 Medical sciences Medicine
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