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Given and acquired risk factors in cognitive decline, the development of Mild Cognitive Impairment, and Alzheimer’s Disease: results of a prospective, population-based, longitudinal study

Degen, Christina

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Abstract

In this dissertation, three articles on the relative roles of given and acquired risk factors in cognitive aging, the development of mild cognitive impairment and Alzheimer's disease are discussed. Data are derived from the Interdisciplinary Longitudinal Study of Adult Aging (ILSE). In the first article, the role of cholesterol Levels in midlife and during aging as well as the APOE genotype are considered. In the second article, the contribution of the COMT genotype on cognitive aging is investigated. In a third article, the role of Diabetes mellitus Type II on cognitive aging is discussed. I conclude that Lifestyle factors in midlife are more important than given risk factors (e.g. genes) for risk of pathological aging.

Item Type: Dissertation
Supervisor: Schröder, Prof. Dr. Johannes
Place of Publication: Heidelberg
Date of thesis defense: 13 September 2016
Date Deposited: 28 Oct 2016 11:21
Date: 2016
Faculties / Institutes: The Faculty of Behavioural and Cultural Studies > Dean's Office of The Faculty of Behavioural and Cultural Studies
Subjects: 150 Psychology
Controlled Keywords: Demenz, Leichte kognitive Beeinträchtigung, Kognition
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