Directly to content
  1. Publishing |
  2. Search |
  3. Browse |
  4. Recent items rss |
  5. Open Access |
  6. Jur. Issues |
  7. DeutschClear Cookie - decide language by browser settings

Health related quality of life in patients with idiopathic pulmonary fibrosis in clinical practice: insights-IPF registry

Kreuter, Michael ; Swigris, Jeff ; Pittrow, David ; Geier, Silke ; Klotsche, Jens ; Prasse, Antje ; Wirtz, Hubert ; Koschel, Dirk ; Andreas, Stefan ; Claussen, Martin ; Grohé, Christian ; Wilkens, Henrike ; Hagmeyer, Lars ; Skowasch, Dirk ; Meyer, Joachim F. ; Kirschner, Joachim ; Gläser, Sven ; Herth, Felix J. F. ; Welte, Tobias ; Neurohr, Claus ; Schwaiblmair, Martin ; Held, Matthias ; Bahmer, Thomas ; Frankenberger, Marion ; Behr, Jürgen

In: Respiratory Research, 18 (2017), Nr. 139. pp. 1-10. ISSN 1465-993X

[img]
Preview
PDF, English
Download (817kB) | Lizenz: Creative Commons LizenzvertragHealth related quality of life in patients with idiopathic pulmonary fibrosis in clinical practice: insights-IPF registry by Kreuter, Michael ; Swigris, Jeff ; Pittrow, David ; Geier, Silke ; Klotsche, Jens ; Prasse, Antje ; Wirtz, Hubert ; Koschel, Dirk ; Andreas, Stefan ; Claussen, Martin ; Grohé, Christian ; Wilkens, Henrike ; Hagmeyer, Lars ; Skowasch, Dirk ; Meyer, Joachim F. ; Kirschner, Joachim ; Gläser, Sven ; Herth, Felix J. F. ; Welte, Tobias ; Neurohr, Claus ; Schwaiblmair, Martin ; Held, Matthias ; Bahmer, Thomas ; Frankenberger, Marion ; Behr, Jürgen underlies the terms of Creative Commons Attribution 3.0 Germany

Citation of documents: Please do not cite the URL that is displayed in your browser location input, instead use the DOI, URN or the persistent URL below, as we can guarantee their long-time accessibility.

Abstract

Background: The INSIGHTS-IPF registry provides one of the largest data sets of clinical data and self-reported patient related outcomes including health related quality of life (QoL) on patients with idiopathic pulmonary fibrosis (IPF). We aimed to describe associations of various QoL instruments between each other and with patient characteristics at baseline. Methods: Six hundred twenty-three IPF patients with available QoL data (St George’s Respiratory Questionnaire SGRQ, UCSD Shortness-of-Breath Questionnaire SoB, EuroQol visual analogue scale and index EQ-5D, Well-being Index WHO-5) were analysed. Mean age was 69.6 ± 8.7 years, 77% were males, mean disease duration 2.0 ± 3.3 years, FVC pred was 67.5 ± 17.8%, DLCO pred 35.6 ± 17%. Results: Mean points were SGRQ total 48.3, UCSD SoB 47.8, EQ-5D VAS 66.8, and WHO-5 13.9. These instruments had a high or very high correlation (exception WHO-5 to EQ-5D VAS with moderate correlation). On bivariate analysis, QoL by SGRQ total was statistically significantly associated with clinical symptoms (NYHA; p &lt; 0.001), number of comorbidities (p < 0.05), hospitalisation rate (p < 0.01) and disease severity (as measured by GAP score, CPI, FVC and 6-min walk test; p < 0.05 each). Multivariate analyses showed a significant association between QoL (by SGRQ total) and IPF duration, FVC, age, NYHA class and indication for long-term oxygen treatment. Conclusions: Overall, IPF patients under real-life conditions have lower QoL compared to those in clinical studies. There is a meaningful relationship between QoL and various patient characteristics. Trial registration: The INSIGHTS-IPF registry is registered at Clinicaltrials.gov (NCT01695408).

Item Type: Article
Journal or Publication Title: Respiratory Research
Volume: 18
Number: 139
Publisher: BioMed Central
Place of Publication: London
Date Deposited: 21 Jul 2017 07:20
Date: 2017
ISSN: 1465-993X
Page Range: pp. 1-10
Faculties / Institutes: Medizinische Fakultät Heidelberg > Thoraxklinik Heidelberg gGmbH
Subjects: 610 Medical sciences Medicine
About | FAQ | Contact | Imprint |
OA-LogoDINI certificate 2013Logo der Open-Archives-Initiative