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Outcome after resection of Adrenocortical Carcinoma liver metastases: a retrospective study

Baur, Johannes ; Büntemeyer, Tjark-Ole ; Megerle, Felix ; Deutschbein, Timo ; Spitzweg, Christine ; Quinkler, Marcus ; Nawroth, Peter ; Kroiss, Matthias ; Germer, Christoph-Thomas ; Fassnacht, Martin ; Steger, Ulrich

In: BMC Cancer, 17 (2017), Nr. 522. pp. 1-10. ISSN 1471-2407

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Download (899kB) | Lizenz: Creative Commons LizenzvertragOutcome after resection of Adrenocortical Carcinoma liver metastases: a retrospective study by Baur, Johannes ; Büntemeyer, Tjark-Ole ; Megerle, Felix ; Deutschbein, Timo ; Spitzweg, Christine ; Quinkler, Marcus ; Nawroth, Peter ; Kroiss, Matthias ; Germer, Christoph-Thomas ; Fassnacht, Martin ; Steger, Ulrich underlies the terms of Creative Commons Attribution 3.0 Deutschland

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Abstract

Background: Metastatic Adrenocortical Carcinoma (ACC) is a rare malignancy with a poor 5-year-survival rate (<15%). A surgical approach is recommended in selected patients if complete resection of distant metastasis can be achieved. To date there are only limited data on the outcome after surgical resection of hepatic metastases of ACC. Methods: A retrospective analysis of the German Adrenocortical Carcinoma Registry was conducted. Patients with liver metastases of ACC but without extrahepatic metastases or incomplete tumour resection were included. Results: Seventy-seven patients fulfilled these criteria. Forty-three patients underwent resection of liver metastases of ACC. Complete tumour resection (R0) could be achieved in 30 (69.8%). Median overall survival after liver resection was 76.1 months in comparison to 10.1 months in the 34 remaining patients with unresected liver metastases (p < 0.001). However, disease free survival after liver resection was only 9.1 months. Neither resection status (R0/R1) nor extent of liver resection were significant predictive factors for overall survival. Patients with a time interval to the first metastasis/recurrence (TTFR) of greater than 12 months or solitary liver metastases showed significantly prolonged survival. Conclusions: Liver resection in the case of ACC liver metastases can achieve long term survival with a median overall survival of more than 5 years, but disease free survival is short despite metastasectomy. Time to recurrence and single versus multiple metastases are predictive factors for the outcome.

Item Type: Article
Journal or Publication Title: BMC Cancer
Volume: 17
Number: 522
Publisher: BioMed Central
Place of Publication: London; Berlin; Heidelberg
Date Deposited: 09 Aug 2017 13:36
Date: 2017
ISSN: 1471-2407
Page Range: pp. 1-10
Faculties / Institutes: Medizinische Fakultät Heidelberg > Medizinische Universitäts-Klinik und Poliklinik
Subjects: 610 Medical sciences Medicine
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