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Association between abdominal adiposity and subclinical measures of left-ventricular remodeling in diabetics, prediabetics and normal controls without history of cardiovascular disease as measured by magnetic resonance imaging: results from the KORA-FF4 Study

Schlett, Christopher L. ; Lorbeer, Roberto ; Arndt, Carolyn ; Auweter, Sigrid ; Machann, Jürgen ; Hetterich, Holger ; Linkohr, Birgit ; Rathmann, Wolfgang ; Peters, Annette ; Bamberg, Fabian

In: Cardiovascular diabetology, 17 (2018), Nr. 88. pp. 1-12. ISSN 1475-2840

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Download (1MB) | Lizenz: Creative Commons LizenzvertragAssociation between abdominal adiposity and subclinical measures of left-ventricular remodeling in diabetics, prediabetics and normal controls without history of cardiovascular disease as measured by magnetic resonance imaging: results from the KORA-FF4 Study by Schlett, Christopher L. ; Lorbeer, Roberto ; Arndt, Carolyn ; Auweter, Sigrid ; Machann, Jürgen ; Hetterich, Holger ; Linkohr, Birgit ; Rathmann, Wolfgang ; Peters, Annette ; Bamberg, Fabian underlies the terms of Creative Commons Attribution 4.0

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Abstract

Objectives: Local, abdominal fat depots may be related to alterations in cardiac function and morphology due to a metabolic linkage. Thus, we aimed to determine their association with subtle cardiac changes and the potential interaction with hyperglycemic metabolic states.

Methods: Subjects from the general population and without history of cardiovascular disease were drawn from the Cooperative Health Research in the Region of Augsburg FF4 cohort and underwent 3 T cardiac and body MRI. Measures of abdominal adiposity such as hepatic proton-density fat fraction [PDFFhepatic], subcutaneous (SAT) and visceral abdominal fat (VAT) as well as established cardiac left-ventricular (LV) measures including LV remodeling index (LVCI) were derived. Associations were determined using linear regression analysis based on standard deviation normalized predictors.

Results: Among a total of 374 subjects (56.2 ± 9.1 years, 58% males), 49 subjects had diabetes, 99 subjects had prediabetes and 226 represented normal controls. Only subtle cardiac alterations were observed (e.g. LVCI: 1.13 ± 0.30). While SAT was not associated, increasing VAT and increasing PDFFhepatic were independently associated with increasing LVCI (β = 0.11 and 0.06, respectively), decreasing LV end-diastolic volume (β = − 6.70 and 3.23, respectively), and decreasing LV stroke volume (β = − 3.91 and − 2.20, respectively). Hyperglycemic state did not modify the associations between VAT or PDFF and LV measures (interaction term: all p ≥ 0.29).

Conclusion: In a healthy population, VAT but also PDFFhepatic were associated with subclinical measures of LV remodeling without evidence for a modifying effect of hyperglycemic state.

Item Type: Article
Journal or Publication Title: Cardiovascular diabetology
Volume: 17
Number: 88
Publisher: BioMed Central
Place of Publication: London
Date Deposited: 25 Jun 2018 06:50
Date: 2018
ISSN: 1475-2840
Page Range: pp. 1-12
Faculties / Institutes: Medizinische Fakultät Heidelberg > Radiologische Universitätsklinik
Subjects: 610 Medical sciences Medicine
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