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Whole brain radiation therapy alone versus radiosurgery for patients with 1–10 brain metastases from small cell lung cancer (ENCEPHALON Trial): study protocol for a randomized controlled trial

Bernhardt, Denise ; Hommertgen, Adriane ; Schmitt, Daniela ; El Shafie, Rami ; Paul, Angela ; König, Laila ; Mair-Walther, Johanna ; Krisam, Johannes ; Klose, Christina ; Welzel, Thomas ; Hörber-Rieber, Juliane ; Kappes, Jutta ; Thomas, Michael ; Heußel, Claus Peter ; Steins, Martin ; Kieser, Meinhard ; Debus, Jürgen ; Rieken, Stefan

In: Trials, 19 (2018), Nr. 388. pp. 1-8. ISSN 1468-6694

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Download (799kB) | Lizenz: Creative Commons LizenzvertragWhole brain radiation therapy alone versus radiosurgery for patients with 1–10 brain metastases from small cell lung cancer (ENCEPHALON Trial): study protocol for a randomized controlled trial by Bernhardt, Denise ; Hommertgen, Adriane ; Schmitt, Daniela ; El Shafie, Rami ; Paul, Angela ; König, Laila ; Mair-Walther, Johanna ; Krisam, Johannes ; Klose, Christina ; Welzel, Thomas ; Hörber-Rieber, Juliane ; Kappes, Jutta ; Thomas, Michael ; Heußel, Claus Peter ; Steins, Martin ; Kieser, Meinhard ; Debus, Jürgen ; Rieken, Stefan underlies the terms of Creative Commons Attribution 3.0 Germany

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Abstract

Background: Conventional whole brain radiotherapy (WBRT) has been established as the treatment standard in patients with cerebral metastases from small-cell lung cancer (SCLC), however, it has only modest efficacy and limited prospective data is available for WBRT as well as local treatments such as stereotactic radiosurgery (SRS).

Methods/design: The present single-center prospective randomized study, conducted at Heidelberg University Hospital, compares neurocognitive function, as objectively measured by significant deterioration in Hopkins Verbal Learning Test – Revised total recall at 3 months. Fifty-six patients will be randomized to receive either SRS of all brain metastases (up to ten lesions) or WBRT. Secondary endpoints include intracranial progression (local tumor progression and number of new cerebral metastases), extracranial progression, overall survival, death due to brain metastases, local (neurological) progression-free survival, progression-free survival, changes in other cognitive performance measures, quality of life and toxicity.

Discussion: Recent evidence suggests that SRS might be a promising treatment option for SCLC patients with brain metastases. The present trial is the first to prospectively investigate the treatment response, toxicity and neurocognition of WBRT and SRS in SCLC patients.

Trial registration: Clinicaltrials.gov NCT03297788 . Registered September 29, 2017.

Item Type: Article
Journal or Publication Title: Trials
Volume: 19
Number: 388
Publisher: BioMed Central
Place of Publication: London
Date Deposited: 23 Jul 2018 12:23
Date: 2018
ISSN: 1468-6694
Page Range: pp. 1-8
Faculties / Institutes: Service facilities > German Cancer Research Center (DKFZ)
Medizinische Fakultät Heidelberg > Radiologische Universitätsklinik
Medizinische Fakultät Heidelberg > Institut für Medizinische Biometrie und Informatik
Medizinische Fakultät Heidelberg > Thoraxklinik Heidelberg gGmbH
Medizinische Fakultät Heidelberg > Heidelberg Ion-Beam Therapy Center (HIT)
Subjects: 610 Medical sciences Medicine
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