In: Cardiovascular diabetology, 17 (2018), Nr. 125. S. 1-12. ISSN 1475-2840
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Abstract
Objectives: The study sought to assess the prognostic impact of type 2 diabetes in patients presenting with ventricular tachyarrhythmias on admission.
Background: Data regarding the prognostic outcome of diabetics presenting with ventricular tachyarrhythmias is limited.
Methods: A large retrospective registry was used including all consecutive patients presenting with ventricular tachycardia (VT) and fibrillation (VF) on admission from 2002 to 2016. Patients with type 2 diabetes (diabetics) were compared to non-diabetics applying multivariable Cox regression models and propensity-score matching for evaluation of the primary prognostic endpoint of long-term all-cause mortality at 2 years. Secondary prognostic endpoints were cardiac death at 24 h, in-hospital death at index, all-cause mortality at 30 days, all-cause mortality in patients surviving index hospitalization at 2 years (i.e. “after discharge”) and rehospitalization due to recurrent ventricular tachyarrhythmias at 2 years.
Results: In 2411 unmatched high-risk patients with ventricular tachyarrhythmias, diabetes was present in 25% compared to non-diabetics (75%). Rates of VT (57% vs. 56%) and VF (43% vs. 44%) were comparable in both groups. Multivariable Cox regression models revealed diabetics associated with the primary endpoint of long-term all-cause mortality at 2 years (HR = 1.513; p = 0.001), which was still proven after propensity score matching (46% vs. 33%, log rank p = 0.001; HR = 1.525; p = 0.001). The rates of secondary endpoints were higher for in-hospital death at index, all-cause mortality at 30 days, as well as after discharge, but not for cardiac death at 24 h or rehospitalization due to recurrent ventricular tachyarrhythmias.
Conclusion: Presence of type 2 diabetes is independently associated with an increase of all-cause mortality in patients presenting with ventricular tachyarrhythmias on admission.
Dokumententyp: | Artikel |
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Titel der Zeitschrift: | Cardiovascular diabetology |
Band: | 17 |
Nummer: | 125 |
Verlag: | BioMed Central |
Ort der Veröffentlichung: | London |
Erstellungsdatum: | 18 Okt. 2018 13:03 |
Erscheinungsjahr: | 2018 |
ISSN: | 1475-2840 |
Seitenbereich: | S. 1-12 |
Institute/Einrichtungen: | Medizinische Fakultät Mannheim > Core Facility Medizinische Statistik
Medizinische Fakultät Heidelberg und Uniklinikum > Radiologische Universitätsklinik |
DDC-Sachgruppe: | 610 Medizin |
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