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Low self-reported sports activity before stroke predicts poor one-year-functional outcome after first-ever ischemic stroke in a population-based stroke register

Urbanek, Christian ; Gokel, Viola ; Safer, Anton ; Becher, Heiko ; Grau, Armin J. ; Buggle, Florian ; Palm, Frederick

In: BMC Neurology, 18 (2018), Nr. 181. pp. 1-10. ISSN 1471-2377

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Download (641kB) | Lizenz: Creative Commons LizenzvertragLow self-reported sports activity before stroke predicts poor one-year-functional outcome after first-ever ischemic stroke in a population-based stroke register by Urbanek, Christian ; Gokel, Viola ; Safer, Anton ; Becher, Heiko ; Grau, Armin J. ; Buggle, Florian ; Palm, Frederick underlies the terms of Creative Commons Attribution 4.0

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Abstract

Background: Physical activity (PA) is associated with lower risk of stroke. We tested the hypothesis that lack of pre-stroke PA is an independent predictor of poor outcome after first-ever ischemic stroke.

Methods: We assessed recent self-reported PA and other potential predictors for loss of functional independence - modified Rankin Scale (mRS) > 2 - one year after first-ever ischemic stroke in 1370 patients registered between 2006 and 2010 in the Ludwigshafen Stroke Study, a population-based stroke registry.

Results: After 1 year, 717 (52.3%) of patients lost their independence including 251 patients (18.3%) who had died. In multivariate logistic regression analysis lack of regular PA prior to stroke (Odds Ratio (OR) 1.7, Confidence Interval (CI) 1.1–2.5), independently predicted poor outcome together with higher age (65–74: OR 1.7; CI 1.1–2.8, 75–84 years: OR 3.3; CI 2.1–5.3; ≥85 years OR 14.5; CI 7.4–28.5), female sex (OR 1.5; CI 1.1–2.1), diabetes mellitus (OR 1.8; CI 1.3–2.5), stroke severity (OR 1.2; CI 1.1–1.2), probable atherothrombotic stroke etiology (OR 1.8; CI 1.1–2.8) and high leukocyte count (> 9.000/mm3; OR 1.4; CI 1.0–1.9) at admission. Subclassifying unknown stroke etiology, embolic stroke of unknown source (ESUS; n = 40, OR 2.2; CI 0.9–5.5) tended to be associated with loss of independence.

Conclusion: In addition to previously reported factors, lack of PA prior to stroke as potential indicator of worse physical condition, high leukocyte count at admission as indicator of the inflammatory response and probable atherothrombotic stroke etiology might be independent predictors for non-functional independence in first-ever ischemic stroke.

Item Type: Article
Journal or Publication Title: BMC Neurology
Volume: 18
Number: 181
Publisher: BioMed Central ; Springer
Place of Publication: London ; Heidelberg
Date Deposited: 19 Nov 2018 16:32
Date: 2018
ISSN: 1471-2377
Page Range: pp. 1-10
Faculties / Institutes: Medizinische Fakultät Heidelberg > Neurologische Universitätsklinik
Medizinische Fakultät Heidelberg > Institut für Public Health (IPH)
Subjects: 610 Medical sciences Medicine
Uncontrolled Keywords: Stroke, Cerebral infarction, Outcome, Physical activity, Predictors, Risk factors
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