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Understanding the role of miR-122 in Colorectal Cancer liver metastasis

Guan, Sha

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In general, our findings suggest that miR-122 is a tumor suppressor in colorectal cancer, and regulates tumor growth by multiple mechanisms including the silencing of RABL6 as well as enhancing P21 activation. This particular activity in the context of liver metastasis implicates miR-122 as a potential line of defence against the establishment of CRC liver metastasis, and also supports a potential use of miR-122 in the therapy of advanced CRC with liver metastasis.

Document type: Dissertation
Supervisor: Allgayer, Prof. Dr. Heike
Date of thesis defense: 17 September 2018
Date Deposited: 21 Nov 2018 12:50
Date: 2018
Faculties / Institutes: Medizinische Fakultät Mannheim > Zentrum für Biomedizin und Medizintechnik (CBTM)
DDC-classification: 610 Medical sciences Medicine
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