In: BMC Research Notes, 11 (2018), Nr. 879. pp. 1-7. ISSN 1756-0500
Preview |
PDF, English
- main document
Download (1MB) | Lizenz: Creative Commons Attribution 4.0 |
Abstract
Objective: The mortality associated with sepsis remains unacceptably high, despite modern high-quality intensive care. Based on the results from previous studies, anaemia and its management in patients with sepsis appear to impact outcomes; however, the transfusion policy is still being debated, and the ideal approach may be extremely specific to the individual. This study aimed to investigate the long-term impact of anaemia requiring red blood cell (RBC) transfusion on mortality and disease severity in patients with sepsis. We studied a general surgical intensive care unit (ICU) population, excluding cardiac surgery patients. 435 patients were enrolled in this observational study between 2012 and 2016.
Results: Patients who received RBC transfusion between 28 days before and 28 days after the development of sepsis (n = 302) exhibited a significantly higher 90-day mortality rate (34.1% vs 19.6%; P = 0.004, Kaplan–Meier analysis). This association remained significant after adjusting for confounders in the multivariate Cox regression analysis (hazard ratio 1.68; 95% confidence interval 1.03–2.73; P = 0.035). Patients who received transfusions also showed significantly higher morbidity scores, such as SOFA scores, and ICU lengths of stay compared to patients without transfusions (n = 133). Our results indicate that anaemia and RBC transfusion are associated with unfavourable outcomes in patients with sepsis.
Document type: | Article |
---|---|
Journal or Publication Title: | BMC Research Notes |
Volume: | 11 |
Number: | 879 |
Publisher: | BioMed Central |
Place of Publication: | London |
Date Deposited: | 08 Feb 2019 08:59 |
Date: | 2018 |
ISSN: | 1756-0500 |
Page Range: | pp. 1-7 |
Faculties / Institutes: | Medizinische Fakultät Heidelberg > Chirurgische Universitätsklinik |
DDC-classification: | 610 Medical sciences Medicine |
Uncontrolled Keywords: | Sepsis, Red blood cell transfusion, Surgical ICU, Mortality, Organ dysfunction, Survival, Organ support, Morbidity |