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Gut microbiome patterns correlate with higher postoperative complication rates after pancreatic surgery

Schmitt, Felix C. F. ; Brenner, Thorsten ; Uhle, Florian ; Loesch, Svenja ; Hackert, Thilo ; Ulrich, Alexis ; Hofer, Stefan ; Dalpke, Alexander H. ; Weigand, Markus A. ; Boutin, Sébastien

In: BMC Microbiology, 19 (2019), Nr. 42. pp. 1-13. ISSN 1471-2180

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Download (1MB) | Lizenz: Creative Commons LizenzvertragGut microbiome patterns correlate with higher postoperative complication rates after pancreatic surgery by Schmitt, Felix C. F. ; Brenner, Thorsten ; Uhle, Florian ; Loesch, Svenja ; Hackert, Thilo ; Ulrich, Alexis ; Hofer, Stefan ; Dalpke, Alexander H. ; Weigand, Markus A. ; Boutin, Sébastien underlies the terms of Creative Commons Attribution 4.0

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Abstract

Abstract Background Postoperative complications are of great relevance in daily clinical practice, and the gut microbiome might play an important role by preventing pathogens from crossing the intestinal barrier. The two aims of this prospective clinical pilot study were: (1) to examine changes in the gut microbiome following pancreatic surgery, and (2) to correlate these changes with the postoperative course of the patient. Results In total, 116 stool samples of 32 patients undergoing pancreatic surgery were analysed by 16S-rRNA gene next-generation sequencing. One sample per patient was collected preoperatively in order to determine the baseline gut microbiome without exposure to surgical stress and/or antibiotic use. At least two further samples were obtained within the first 10 days following the surgical procedure to observe longitudinal changes in the gut microbiome. Whenever complications occurred, further samples were examined. Based on the structure of the gut microbiome, the samples could be allocated into three different microbial communities (A, B and C). Community B showed an increase in Akkermansia, Enterobacteriaceae and Bacteroidales as well as a decrease in Lachnospiraceae, Prevotella and Bacteroides. Patients showing a microbial composition resembling community B at least once during the observation period were found to have a significantly higher risk for developing postoperative complications (B vs. A, odds ratio = 4.96, p < 0.01**; B vs. C, odds ratio = 2.89, p = 0.019*). Conclusions The structure of the gut microbiome is associated with the development of postoperative complications.

Item Type: Article
Journal or Publication Title: BMC Microbiology
Volume: 19
Number: 42
Publisher: BioMed Central ; Springer
Place of Publication: London ; Berlin, Heidelberg
Date Deposited: 09 Apr 2019 13:00
Date: 2019
ISSN: 1471-2180
Page Range: pp. 1-13
Faculties / Institutes: Medizinische Fakultät Heidelberg > Chirurgische Universitätsklinik
Medizinische Fakultät Heidelberg > Universitätsklinik für Anaesthesiologie
Subjects: 610 Medical sciences Medicine
Uncontrolled Keywords: Pancreas, Postoperative complications, Gut microbiome, 16S RNA gene sequencing, Inflammation, Sepsis
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