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Targeting of activated fibroblasts for imaging and therapy

Lindner, Thomas ; Loktev, Anastasia ; Giesel, Frederik ; Kratochwil, Clemens ; Altmann, Annette ; Haberkorn, Uwe

In: EJNMMI Radiopharmacy and Chemistry, 4 (2019), Nr. 16. pp. 1-15. ISSN 2365-421X

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Download (1MB) | Lizenz: Creative Commons LizenzvertragTargeting of activated fibroblasts for imaging and therapy by Lindner, Thomas ; Loktev, Anastasia ; Giesel, Frederik ; Kratochwil, Clemens ; Altmann, Annette ; Haberkorn, Uwe underlies the terms of Creative Commons Attribution 4.0

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Abstract

Tumors form a complex environment consisting of a variety of non-malignant cells. Especially cancer-associated fibroblasts have been shown to have an important role for different aspects of malignant tumors such as migration, metastasis, resistance to chemotherapy and immunosuppression. Therefore, a targeting of these cells may be useful for both imaging and therapy. In this respect, an interesting target is the fibroblast activation protein (FAP) which is expressed in activated fibroblasts, but not in quiescent fibroblasts, giving the opportunity to use this membrane-anchored enzyme as a target for radionuclide-based approaches for diagnosis and treatment of tumors and for the diagnosis of non-malignant disease associated with a remodelling of the extracellular matrix.

Item Type: Article
Journal or Publication Title: EJNMMI Radiopharmacy and Chemistry
Volume: 4
Number: 16
Publisher: Springer International Publishing ; SpringerOpen
Place of Publication: Cham ; Heidelberg
Date Deposited: 20 Aug 2019 12:48
Date: 2019
ISSN: 2365-421X
Page Range: pp. 1-15
Faculties / Institutes: Service facilities > German Cancer Research Center (DKFZ)
Medizinische Fakultät Heidelberg > Radiologische Universitätsklinik
Subjects: 610 Medical sciences Medicine
Uncontrolled Keywords: Cancer-associated fibroblast, Tumor stroma, Fibroblast activation protein, Inhibitors, Imaging
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