Download (948Kb) | Lizenz: Print on Demand
Conjugation of a lysosomotropic detergent to tumor affine peptides (octreotate and melanocortin analogous) resulted in receptor mediated uptake of the peptide conjugates into tumor cells expressing the peptide receptors. During intracellular trafficking the lysosomotropic detergent was cleaved from the peptide. Cytotoxicity studies showed IC50 values in the range of 11-72 µM caused by lysosomal rupture as proven by confocal laser scanning microscopy. For cells not expressing the receptors the conjugates were less cytotoxic.
|Faculties / Institutes:||Service facilities > German Cancer Research Center (DKFZ)|
|Subjects:||570 Life sciences|