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Signal Recognition Particle-dependent Membrane Insertion of Mouse Invariant Chain: A Membrane-spanning Protein with a Cytoplasmically Exposed Amino Terminus

Lipp, Joachim ; Dobberstein, Bernhard

In: The Journal of Cell Biology, 102 (1986), pp. 2169-2175

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Invariant (Ii) chain is a membrane-spanning protein that is found associated intracellularly with class II histocompatibility antigens. In the endoplasmic reticulum Ii chain spans the membrane and exposes the NH2 terminus on the cytoplasmic and the COOH terminus on the lumenal side. This orientation across the membrane is demonstrated directly with the monoclonal antibody In-l, which exclusively recognizes the NH2 terminal cytoplasmically exposed part of Ii chain. Membrane insertion of Ii chain requires signal recognition particle and docking protein. When tested in a wheat germ cell free system, signal recognition particle arrests translation of Ii chain. No signal sequence is cleaved from Ii chain upon membrane insertion.

Item Type: Article
Journal or Publication Title: The Journal of Cell Biology
Volume: 102
Date Deposited: 22 Jul 2008 14:50
Date: 1986
Page Range: pp. 2169-2175
Faculties / Institutes: Service facilities > Center for Molecular Biology Heidelberg
Subjects: 570 Life sciences
Schriftenreihe ID: Works by Bernhard Dobberstein
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