In: BMC Proceedings, 8 (2014), Nr. S1. . ISSN 1753-6561

Vorschau

PDF, Englisch Download (122kB) | Lizenz: Genetic Analysis Workshop 18: Methods and strategies for analyzing human sequence and phenotype data in members of extended pedigrees von Bickeböller, Heike ; Bailey, Julia N. ; Beyene, Joseph ; Cantor, Rita M. ; Cordell, Heather J. ; Culverhouse, Robert C. ; Engelman, Corinne D. ; Fardo, David W ; Ghosh, Saurabh ; König, Inke R. ; Bermejo, Justo Lorenzo ; Melton, Phillip E. ; Santorico, Stephanie A. ; Satten, Glen A. ; Sun, Lei ; Tintle, Nathan L. ; Ziegler, Andreas ; MacCluer, Jean W. ; Almasy, Laura steht unter einer Creative Commons Namensnennung 3.0 Deutschland

Abstract

Genetic Analysis Workshop 18 provided a platform for developing and evaluating statistical methods to analyze whole-genome sequence data from a pedigree-based sample. In this article we present an overview of the data sets and the contributions that analyzed these data. The family data, donated by the Type 2 Diabetes Genetic Exploration by Next-Generation Sequencing in Ethnic Samples Consortium, included sequence-level genotypes based on sequencing and imputation, genome-wide association genotypes from prior genotyping arrays, and phenotypes from longitudinal assessments. The contributions from individual research groups were extensively discussed before, during, and after the workshop in theme-based discussion groups before being submitted for publication.