Direkt zum Inhalt
  1. Publizieren |
  2. Suche |
  3. Browsen |
  4. Neuzugänge rss |
  5. Open Access |
  6. Rechtsfragen |
  7. EnglishCookie löschen - von nun an wird die Spracheinstellung Ihres Browsers verwendet.

Comparison of breast sequential and simultaneous integrated boost using the biologically effective dose volume histogram (BEDVH)

Aly, Moamen M. O. M. ; Abo-Madyan, Yasser ; Jahnke, Lennart ; Wenz, Frederik ; Glatting, Gerhard

In: Radiation Oncology, 11 (2016), Nr. 16. S. 1-7. ISSN 1748-717X

[thumbnail of 13014_2016_Article_590.pdf]
Vorschau
PDF, Englisch
Download (2MB) | Lizenz: Creative Commons LizenzvertragComparison of breast sequential and simultaneous integrated boost using the biologically effective dose volume histogram (BEDVH) von Aly, Moamen M. O. M. ; Abo-Madyan, Yasser ; Jahnke, Lennart ; Wenz, Frederik ; Glatting, Gerhard steht unter einer Creative Commons Namensnennung 3.0 Deutschland

Zitieren von Dokumenten: Bitte verwenden Sie für Zitate nicht die URL in der Adresszeile Ihres Webbrowsers, sondern entweder die angegebene DOI, URN oder die persistente URL, deren langfristige Verfügbarkeit wir garantieren. [mehr ...]

Abstract

Purpose: A method is presented to radiobiologically compare sequential (SEQ) and simultaneously integrated boost (SIB) breast radiotherapy. Methods: The method is based on identically prescribed biologically effective dose (iso-BED) which was achieved by different prescribed doses due to different fractionation schemes. It is performed by converting the calculated three-dimensional dose distribution to the corresponding BED distribution taking into consideration the different number of fractions for generic α/β ratios. A cumulative BED volume histogram (BEDVH) is then derived from the BED distribution and is compared for the two delivery schemes. Ten breast cancer patients (4 right-sided and 6 left-sided) were investigated. Two tangential intensity modulated whole breast beams with two other oblique (with different gantry angles) beams for the boost volume were used. The boost and the breast target volumes with either α/β = 10 or 3 Gy, and ipsi-lateral and contra-lateral lungs, heart, and contra-lateral breast as organs at risk (OARs) with α/β = 3 Gy were compared. Results: Based on the BEDVH comparisons, the use of SIB reduced the biological breast mean dose by about 3%, the ipsi-lateral lung and heart by about 10%, and contra-lateral breast and lung by about 7%. Conclusion: BED based comparisons should always be used in comparing plans that have different fraction sizes. SIB schemes are dosimetrically more advantageous than SEQ in breast target volume and OARs for equal prescribed BEDs for breast and boost.

Dokumententyp: Artikel
Titel der Zeitschrift: Radiation Oncology
Band: 11
Nummer: 16
Verlag: BioMed Central
Ort der Veröffentlichung: London
Erstellungsdatum: 01 Mrz. 2016 08:07
Erscheinungsjahr: 2016
ISSN: 1748-717X
Seitenbereich: S. 1-7
Institute/Einrichtungen: Medizinische Fakultät Mannheim > Institut für Klinische Radiologie
Medizinische Fakultät Mannheim > Klinik für Strahlentherapie und Radioonkologie
DDC-Sachgruppe: 610 Medizin
Leitlinien | Häufige Fragen | Kontakt | Impressum |
OA-LogoDINI-Zertifikat 2013Logo der Open-Archives-Initiative