In: Journal of Neuroinflammation, 10 (2013), Nr. 7. S. 1-6. ISSN 1742-2094
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Abstract
Recently, we discovered a novel serum and cerebrospinal fluid (CSF) autoantibody (anti-Ca) to Purkinje cells in a patient with autoimmune cerebellar ataxia (ACA) and identified the RhoGTPase-activating protein 26 (ARHGAP26; alternative designations include GTPase regulator associated with focal adhesion kinase pp125, GRAF, and oligophrenin-1-like protein, OPHN1L) as the target antigen. Here, we report on two new cases of ARHGAP26 autoantibody-positive ACA that were first diagnosed after publication of the index case study. While the index patient developed ACA following an episode of respiratory infection with still no evidence for malignancy 52 months after onset, neurological symptoms heralded ovarian cancer in one of the patients described here. Our finding of anti-Ca/anti-ARHGAP26 antibodies in two additional patients supports a role of autoimmunity against ARHGAP26 in the pathogenesis of ACA. Moreover, the finding of ovarian cancer in one of our patients suggests that anti-Ca/anti-ARHGAP26-positive ACA might be of paraneoplastic aetiology in some cases. In conclusion, testing for anti-Ca/anti-ARHGAP26 should be included in the diagnostic work-up of patients with ACA, and an underlying tumour should be considered in patients presenting with anti-Ca/ARHGAP26 antibody-positive ACA.
Dokumententyp: | Artikel |
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Titel der Zeitschrift: | Journal of Neuroinflammation |
Band: | 10 |
Nummer: | 7 |
Verlag: | BioMed Central |
Ort der Veröffentlichung: | London |
Erstellungsdatum: | 27 Jan. 2017 13:30 |
Erscheinungsjahr: | 2013 |
ISSN: | 1742-2094 |
Seitenbereich: | S. 1-6 |
Institute/Einrichtungen: | Zentrale und Sonstige Einrichtungen > Interdisziplinäres Zentrum für Neurowissenschaften
Medizinische Fakultät Heidelberg und Uniklinikum > Neurologische Universitätsklinik |
DDC-Sachgruppe: | 610 Medizin |