In: Acta haematologica, 128 (2012), Nr. 1. pp. 53-59. ISSN 0001-5792
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Abstract
Background: Climacteric increases the risk of thrombotic events by alteration of plasmatic coagulation. Up to now, less is known about changes in platelet-(PMP) and endothelial cell-derived microparticles (EMP). Methods: In this prospective study, plasma levels of microparticles (MP) were compared in 21 premenopausal and 19 postmenopausal women. Results: No altered numbers of total MP or EMP were measured within the study groups. However, the plasma values of CD61-exposing MP from platelets/megakaryocytes were higher in premenopausal women (5,364 x 10(6)/l, range 4,384-17,167) as compared to postmenopausal women (3,808 x 10 6 /l, range 2,009–8,850; p = 0.020). This differentiation was also significant for the subgroup of premenopausal women without hormonal contraceptives (5,364 x 10 6 /l, range 4,223–15,916; p = 0.047; n = 15). Furthermore, in premenopausal women, higher plasma levels of PMP exposing CD62P were also present as compared to postmenopausal women (288 x 10 6 /l, range 139–462, vs. 121 x 10 6 /l, range 74–284; p = 0.024). This difference was also true for CD63+ PMP levels (281 x 10 6 /l, range 182–551, vs. 137 x 10 6 /l, range 64–432; p = 0.015). Conclusion: Climacteric lowers the level of PMP but has no impact on the number of EMP in women. These data suggest that PMP and EMP do not play a significant role in enhancing the risk of thrombotic events in healthy, postmenopausal women.
Document type: | Article |
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Journal or Publication Title: | Acta haematologica |
Volume: | 128 |
Number: | 1 |
Publisher: | S. Karger AG |
Date Deposited: | 08 Jan 2015 09:12 |
Date: | 2012 |
ISSN: | 0001-5792 |
Page Range: | pp. 53-59 |
Faculties / Institutes: | Medizinische Fakultät Heidelberg > Universitäts-Frauenklinik |
DDC-classification: | 610 Medical sciences Medicine |
Controlled Keywords: | Klimakterium, Thrombose, Thrombozyt |