Preview |
PDF, English
Download (19MB) | Terms of use |
Abstract
Mechanotransduction plays an important role in the regulation of muscle growth and metabolic signalling in striated muscle. Muscle disuse reduces mechanical input to the muscle, which results in a loss of muscle mass. Here I describe how titin's mechanically activated kinase domain affects muscle growth and metabolism via p62 and Akt signalling. I also demonstrate how changes in metabolic and growth signalling in hibernating grizzly bear help maintain muscle mass under conditions that induce muscle loss in humans and mice. I validated some of these changes in murine myotubes demonstrating that increasing non-essential amino acid levels, increasing Pdk4 levels or suppressing Serpinf1 has a positive effect on growth signalling that extends to non-hibernators.
Document type: | Dissertation |
---|---|
Supervisor: | Kummer, Prof. Dr. Ursula |
Date of thesis defense: | 24 July 2015 |
Date Deposited: | 26 Aug 2015 09:03 |
Date: | 2015 |
Faculties / Institutes: | The Faculty of Bio Sciences > Dean's Office of the Faculty of Bio Sciences |
DDC-classification: | 500 Natural sciences and mathematics 570 Life sciences |
Controlled Keywords: | Winterschlaf , MUSCLE, Stoffwechsel , Wachstum |
Uncontrolled Keywords: | Muscle, Hibernation, Metabolism, Growth, Cell size |