In: Clinical Sarcoma Research, 5 (2015), Nr. 14. pp. 1-7. ISSN 2045-3329
Preview |
PDF, English
Download (892kB) | Lizenz: Creative Commons Attribution 3.0 Germany |
Abstract
Background: Angiosarcomas (AS) are rare vascular malignancies. They are subdivided into primary (PAS) and secondary angiosarcomas (SAS). The objective was to compare the characteristics of AS subtypes. Methods: Eighteen PAS and ten SAS patients treated at our institution between 2004 and 2012 were included in this study. Results: Median age of PAS and SAS patients was 52.9 and 64.2 years, respectively (p = 0.1448). The percentage of women was 27.8% for PAS, but 80.0% for SAS (p = 0.0163). While PAS occurred throughout the body, the majority of SAS arose from the breast (p = 0.0012). All SAS were radiation-induced with a median latency of 7.7 years. The majority of patients with PAS and SAS underwent surgery as primary or recurrence treatment (p > 0.95). Local recurrence was developed by 27.8% of PAS and 50.0% of SAS (p = 0.4119). 61.1% of PAS metastasized, but only 40.0% of SAS (p = 0.4328). Median overall survival for PAS and SAS was 19 and 57 months, respectively (p = 0.2306). Conclusion: Radical surgery remains the mainstay of both primary and recurrence treatment. SAS show a high local recurrence rate, while PAS tend towards developing early metastases. Overall, prognosis is poor for both groups.
Document type: | Article |
---|---|
Journal or Publication Title: | Clinical Sarcoma Research |
Volume: | 5 |
Number: | 14 |
Publisher: | BioMed Central |
Place of Publication: | London |
Date Deposited: | 22 Dec 2015 09:50 |
Date: | 2015 |
ISSN: | 2045-3329 |
Page Range: | pp. 1-7 |
Faculties / Institutes: | Medizinische Fakultät Mannheim > Chirurgische Klinik Medizinische Fakultät Mannheim > Medizinische Klinik - Lehrstuhl für Innere Medizin III |
DDC-classification: | 610 Medical sciences Medicine |