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Modeling of light propagation in skin, and an application to noninvasive diagnostics

Volz, Dietmar

German Title: Modellierung der Lichtausbreitung in der Haut und eine Anwendung für die nicht-invasive Diagnostik

Postscript, English
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Translation of abstract (English)

Diabetics would greatly benefit from a device capable of providing continuous noninvasive monitoring of their blood glucose levels. At present, diabetics rely on pricking their finger to obtain a blood sample which in turn is placed upon a test strip. Life long finger pricking is often accompanied by chronic infections and pain during the lancets prick. Moreover, to significantly reduce longer-term secondary effects of diabetes such as retinopahy, nephropathy or neuropathy on the one hand and to reduce the risk of unnoticed suffering from hypoglycemia on the other hand a more frequent or even continuous monitoring of blood glucose swings is needed. In the past decade several attempts have been made to measure the glucose content of blood in a more compliant fashion. These endeavors will gain importance in the near future. Already nowadays, diabetes ranges among the top civilization deseases, about 10 of all U.S. citizens are living with this diagnosis, European citizens will make up in the future. Many techniques have been suggested for continuous monitoring of glucose, ranging from implanted electrochemical sensors to noninvasive optical methods. So far none of these methods have proven to be sensitive or specific enough for commercial use. The method proposed in this thesis deals with an effect which is based upon changes of the light scattering coefficient in the upper dermal regions of skin induced by glucose dissolved in the interstitial fluid. We will focus on the identification of this coefficient in vivo. As we want to probe our tissue with decoherent light of a single wavelength in the near infrared regime, the physical process is properly described by the radiative transfer equation. The modeling has to face the task of mapping a special measurement setting as well as spatial and temporal varying skin optical properties to a proper boundary value problem formulation for the radiative transfer equation and an effective

Item Type: Dissertation
Supervisor: Jäger, Prof. Dr. Willi
Date of thesis defense: 17 December 2001
Date Deposited: 01 Feb 2002 00:00
Date: 2001
Faculties / Institutes: Service facilities > Interdisciplinary Center for Scientific Computing
Subjects: 510 Mathematics
Controlled Keywords: xxx
Uncontrolled Keywords: noninvasive glucose measurement , radiative transfer equation , skin models , scattering coefficient , diffusion tomography
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