In: The EMBO Journal, 6 (1987), Nr. 6. pp. 1677-1683
Preview |
PDF, English
Download (1MB) | Terms of use |
Abstract
The gene for murine Ia-associated invariant (1i) chains (1131 and 1i41) was characterized by sequence analysis. The gene extends over - 9 kb and is organized in nine exons. Exon 1 encodes the 5' untranslated region and the cytoplasmic segment, exon 2 the membrane spaniing segment and adjacent amino acids and exons 3- 8 the extracytoplasmic portion of 1131. Putative promoter sequences were found upstream of the start of the coding sequence. Between exons 6 and 7 an additional, alternatively spliced exon 6b has been identified. This exon is spliced into the mRNA coding for the li-related Ii41 protein. Exon 6b encodes a cysteine-rich domain of 64 amino acids. It shows a remarkably high homology to the repetitive elements in thyroglobulin, a precursor for thyroid hormone. Based on this homology, it is suggested that this domain (TgR) in Tg and in 1141 may play a role either in hormone formation or as a carrier in the transport of molecules (thyroid hormone or processed antigen respectively) between intracellular compartments.
Document type: | Article |
---|---|
Journal or Publication Title: | The EMBO Journal |
Volume: | 6 |
Number: | 6 |
Date Deposited: | 17 Jun 2008 17:33 |
Date: | 1987 |
Page Range: | pp. 1677-1683 |
Faculties / Institutes: | Service facilities > Center for Molecular Biology Heidelberg |
DDC-classification: | 570 Life sciences |
Uncontrolled Keywords: | invariant chain gene, class II histocompatibility antigens , alternative-splicing , hyroglobulin , antigen processing |
Series: | Works by Bernhard Dobberstein |