Proton therapy has played an important role in the treatment of cancer with radiation therapy for more than 60 years. Active spot scanning to deliver highly conformal dose to the tumor has been developed. However, the availability of proton therapy to the patients is still limited, partly, due to the high costs and sizes of large proton therapy centers. Therefore, a novel compact proton single room facility based on a linear accelerator mounted on a gantry has been proposed, named TULIP (TUrning LInac for Proton therapy). This accelerator allows for active energy variation on a milliseconds time scale. This work aims to assess the possibilities of dose delivery with TULIP to exploit its beneficial features with respect to dose delivery. We developed a software tool, simulating the dose delivery to the tumor. By means of this software tool, we assessed different delivery methods and found 3D spot scanning to be superior to rotational dose delivery with regard to dose and irradiation time. In a second part, we expanded the investigations to dose delivery to moving targets. Due to fast energy variation, we found TULIP to be preferably suitable for rescanning, confirmed by irradiation times of only a few minutes.
|Supervisor:||Oelfke, Prof. Dr. Uwe|
|Place of Publication:||Heidelberg|
|Date of thesis defense:||15 January 2014|
|Date Deposited:||05 Feb 2014 08:28|
|Faculties / Institutes:||The Faculty of Physics and Astronomy > Dekanat der Fakultät für Physik und Astronomie
Service facilities > German Cancer Research Center (DKFZ)
600 Technology (Applied sciences)