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Alzheimer’s disease and retinal neurodegeneration share a consistent stress response of the neurovascular unit

Busch, Stephanie ; Wu, Liang ; Feng, Yuxi ; Gretz, Norbert ; Hoffmann, Sigrid ; Hammes, Hans-Peter

In: Cellular physiology and biochemistry, 30 (2012), Nr. 6. pp. 1436-1443. ISSN 1015-8987

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Background: The pathogenesis of Alzheimer’s disease (AD) is characterized by neuronal injury, activation of microglia and astrocytes, deposition of amyloid-beta and secondary vessel degeneration. In the polycystic kidney disease (PKD) rat model, we observed neuronal injury, microglial activation and vasoregression. We speculated that this neuroretinal degeneration shares important pathogenetic steps with AD. Therefore, we determined the activation of astrocytes and the accumulation of amyloid-beta in PKD retinae. Methods: Immunohistochemistry of PKD retinae for vimentin, carboxymethyllysin, beta-Amyloid 1-42, High-Mobility-Group-Protein B1 and amyloid protein precursor was performed. Results: Adjunct to astrocyte activation, accumulation of beta-Amyloid 1-42 and High-Mobility-Group-Protein B1 in astrocytes and around vessels of the superficial network was found in PKD retinae prior to the onset of vasoregression. Amyloid precursor protein was localized adjacent to the outer segment of photoreceptors in PKD and control rats. The parallel appearance of AD-related peptides indicates an alarmine based response to photoreceptor degeneration and secondary vasoregression. Conclusion: The model has broad overlap with AD and may be suitable to study beneficial pharmacological concepts. Copyright (c) 2012 S. Karger AG, Basel

Document type: Article
Journal or Publication Title: Cellular physiology and biochemistry
Volume: 30
Number: 6
Publisher: S. Karger AG
Date Deposited: 12 Jan 2015 13:19
Date: 2012
ISSN: 1015-8987
Page Range: pp. 1436-1443
Faculties / Institutes: Medizinische Fakultät Mannheim > Zentrum für Medizinische Forschung
Medizinische Fakultät Mannheim > Institut für Klinische Pharmakologie
DDC-classification: 610 Medical sciences Medicine
Controlled Keywords: Alzheimer-Krankheit, Retinopathie
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