Directly to content
  1. Publishing |
  2. Search |
  3. Browse |
  4. Recent items rss |
  5. Open Access |
  6. Jur. Issues |
  7. DeutschClear Cookie - decide language by browser settings

Towards a quantum cascade laser-based implant for the continuous monitoring of glucose

Isensee, Katharina

[img]
Preview
PDF, English
Download (11MB) | Terms of use

Citation of documents: Please do not cite the URL that is displayed in your browser location input, instead use the DOI, URN or the persistent URL below, as we can guarantee their long-time accessibility.

Abstract

The continuous surveillance of the body’s glucose concentration is pivotal for the prevention of short- and long-term health complications for people with diabetes. In this thesis, mid-infrared absorption spectroscopy is investigated as an alternative to conventional enzyme-based glucose monitors. To this end, a quantum cascade laser-based sensor system is designed and implemented with the goal to serve as an optical port for continuous, real-time spectroscopy in vivo. This transflection sensor shows high sensitivity in vitro with a glucose error of prediction as low as 4mg/dL in pure glucose solutions, 10mg=dL in the presence of proteins and 21mg=dL in the presence of other carbohydrates. The impact of the temperature on the optical signal is investigated both theoretically and experimentally. Even under temperature variations up to 15C a glucose prediction error as low as 18:5mg/dL can be achieved. Adding a porous membrane hinders the diffusion of large molecules into the sensor while enabling glucose diffusion on the targeted time scale (<5 minutes). Finally, a stable glucose permeation and concentration prediction over more than 1 month demonstrates the potential of a quantum cascade laser-based transflection technology for application in a long-term implant for continuous glucose sensing.

Item Type: Dissertation
Supervisor: Petrich, Prof. Dr. Wolfgang
Place of Publication: Heidelberg
Date of thesis defense: 12 December 2018
Date Deposited: 19 Dec 2018 12:19
Date: 2018
Faculties / Institutes: The Faculty of Physics and Astronomy > Dekanat der Fakultät für Physik und Astronomie
Subjects: 530 Physics
About | FAQ | Contact | Imprint |
OA-LogoDINI certificate 2013Logo der Open-Archives-Initiative