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Real-time blood oxygenation tomography with multispectral photoacoustics

Kirchner, Thomas

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Abstract

Multispectral photoacoustics is an emerging biomedical imaging modality which combines the penetration depth and resolution of high frequency medical ultrasonography with an optical absorption contrast. This enables tomographic imaging of blood oxygen saturation, a functional biomarker with wide applications. Already, photoacoustic imaging (PAI) is widely applied for small animal imaging in preclinical research. While PAI is a multiscale modality, its translation to clinical research and interventional use remains challenging. The objective of this thesis was to investigate the usefulness of multispectral PAI as a technique for interventional tomographic imaging of blood oxygenation. This thesis presents open challenges alongside research contributions to address them. These contributions are, (1) The design and implementation of an interventional PAI system, (2) Methods for real-time photoacoustic (PA) image processing and quantification of tissue absorption and blood oxygenation, and finally (3) the application of multispectral PAI to translational neurosurgical research – performing the first high spatiotemporal resolution tomography of spreading depolarization, and at the same time the first interventional PAI on any gyrencephalic (folded) brain. Such interventional imaging in neurology is one of many promising fields of application for PAI.

Item Type: Dissertation
Supervisor: Bachert, Prof. Dr. Peter
Date of thesis defense: 25 June 2019
Date Deposited: 06 Aug 2019 06:13
Date: 2019
Faculties / Institutes: The Faculty of Physics and Astronomy > Dekanat der Fakultät für Physik und Astronomie
Service facilities > German Cancer Research Center (DKFZ)
Subjects: 530 Physics
610 Medical sciences Medicine
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