Directly to content
  1. Publishing |
  2. Search |
  3. Browse |
  4. Recent items rss |
  5. Open Access |
  6. Jur. Issues |
  7. DeutschClear Cookie - decide language by browser settings

Biological Dose Accumulation in Image-guided Radiotherapy

Niebuhr, Nina Isabelle

[img] PDF, English
Please note: Access restricted to Repository staff only until 8 January 2021.
Login+Download (21MB) | Terms of use

Citation of documents: Please do not cite the URL that is displayed in your browser location input, instead use the DOI, URN or the persistent URL below, as we can guarantee their long-time accessibility.


Dose accumulation (DA), the computation of the total delivered 3D dose distribution Da of a fractionated radiotherapy treatment using daily patient imaging, is getting established in clinical practice. Although the aim is to estimate the achieved biological outcome of the treatment, the principles of biological effect estimation are currently not followed consistently in the process. In this thesis, the biological effect accumulation approach and total biological dose (bEQD) were derived as a biologically consistent DA workflow. Clinical relevance of bEQD and its dependence on individual workflow aspects were investigated in data from three patient cohorts. It was found that Da systematically underestimates the obtained biological effect, which can be avoided by the use of bEQD. Results showed that this is strongest for late-responding organs at risk (OAR) with low �=� values in dose gradient regions around the target that are prone to organ motion. bEQD to Da deviations occurred locally, in so-called hotspots, showing individual cases of high difference magnitude but only small statistical impact. Hotspots of bEQD - Da deviation around 4 Gy in bladder and rectum were found in patients treated for prostate carcinoma. Hypofractionation increased these deviations strongly up to 8 Gy and also showed clinically relevant deviations in dose-volume analysis. Dose-response correlation in standard fractionation showed only little impact on the DA approaches. Workflow uncertainties are dominated by those from deformable image registration, which are in the same range as the difference between bEQD and Da. bEQD should be considered in the application of treatment adaptation, especially to avoid damage to OARs in individual cases.

Item Type: Dissertation
Supervisor: Seco, Prof. Dr. Joao
Place of Publication: Heidelberg
Date of thesis defense: 17 December 2019
Date Deposited: 13 Jan 2020 09:05
Date: 2021
Faculties / Institutes: The Faculty of Physics and Astronomy > Dekanat der Fakultät für Physik und Astronomie
Subjects: 500 Natural sciences and mathematics
530 Physics
610 Medical sciences Medicine
About | FAQ | Contact | Imprint |
OA-LogoDINI certificate 2013Logo der Open-Archives-Initiative